%PDF-1.6
%
1 0 obj
<<
/AcroForm 2 0 R
/Lang (EN)
/Metadata 3 0 R
/Names 4 0 R
/Outlines 5 0 R
/OutputIntents [6 0 R]
/PageLabels 7 0 R
/PageMode /UseOutlines
/Pages 8 0 R
/Type /Catalog
>>
endobj
9 0 obj
<<
/Author <5472696E652048F879657220526F7365>
/CreationDate (D:20160322101108+05'30')
/Creator (Springer)
/CrossMarkDomains#5B1#5D (springer.com)
/CrossMarkDomains#5B2#5D (springerlink.com)
/CrossmarkDomainExclusive (true)
/CrossmarkMajorVersionDate (2010-04-23)
/ModDate (D:20170125113936+01'00')
/Subject (Drugs in R&D, doi:10.1007/s40268-016-0129-9)
/Title (Population Pharmacokinetic Modelling of FE 999049, a Recombinant Human Follicle-Stimulating Hormone, in Healthy Women After Single Ascending Doses)
/doi (10.1007/s40268-016-0129-9)
/robots (noindex)
>>
endobj
2 0 obj
<<
/DA (/Helv 0 Tf 0 g )
/DR <<
/Encoding <<
/PDFDocEncoding 10 0 R
>>
/Font <<
/Helv 11 0 R
/ZaDb 12 0 R
>>
>>
/Fields []
>>
endobj
3 0 obj
<<
/Length 27154
/Subtype /XML
/Type /Metadata
>>
stream
2016-03-22T10:11:08+05:30
Springer
2017-01-25T11:39:36+01:00
2017-01-25T11:39:36+01:00
application/pdf
doi:10.1007/s40268-016-0129-9
Springer International Publishing
Drugs in R&D, doi:10.1007/s40268-016-0129-9
Population Pharmacokinetic Modelling of FE 999049, a Recombinant Human Follicle-Stimulating Hormone, in Healthy Women After Single Ascending Doses
Trine Høyer Rose
Daniel Röshammar
Lars Erichsen
Lars Grundemar
Johnny T. Ottesen
10.1007/s40268-016-0129-9
2010-04-23
true
springer.com
springerlink.com
"http://dx.doi.org/10.1007/s40268-016-0129-9
10.1007/s40268-016-0129-9
1179-6901
16
2
173
180
journal
Drugs in R&D
The Author(s)
2010-04-23
true
10.1007/s40268-016-0129-9
noindex
springer.com
springerlink.com
VoR
uuid:97fc5556-b3d9-4082-97ce-3ba544ec655d
uuid:c8be8d1d-dba0-40cc-8433-54fc91400b1c
default
1
converted
uuid:a85f32f2-c371-443a-bdd4-1f55b017767c
converted to PDF/A-2b
pdfToolbox
2016-05-05T18:37:31+05:30
converted
uuid:d14dbe29-908f-44e9-bda0-0c4488c5e1b1
converted to PDF/A-2b
pdfToolbox
2016-05-05T18:38:01+05:30
2
B
http://ns.adobe.com/pdfx/1.3/
pdfx
PDF/X ID Schema
external
Mirrors crossmark:MajorVersionDate
CrossmarkMajorVersionDate
Text
external
Mirrors crossmark:CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
Mirrors crossmark:DOI
doi
Text
external
Mirrors crossmark:CrosMarkDomains
CrossMarkDomains
seq Text
internal
A name object indicating whether the document has been modified to include trapping information
robots
Text
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
http://crossref.org/crossmark/1.0/
crossmark
Crossmark Schema
internal
Usual same as prism:doi
DOI
Text
external
The date when a publication was publishe.
MajorVersionDate
Text
internal
CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
CrossMarkDomains
CrossMarkDomains
seq Text
http://prismstandard.org/namespaces/basic/2.0/
prism
Prism Schema
external
This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.
url
URI
external
The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL).
doi
Text
external
ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.
issn
Text
internal
Volume number
volume
Text
internal
Issue number
number
Text
internal
Starting page
startingPage
Text
internal
Ending page
endingPage
Text
external
The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary.
aggregationType
Text
external
Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”
publicationName
Text
external
Copyright
copyright
Text
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
DocumentID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
http://www.niso.org/schemas/jav/1.0/
jav
NISO
external
Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record
journal_article_version
Closed Choice of Text
endstream
endobj
4 0 obj
<<
/Dests 13 0 R
>>
endobj
5 0 obj
<<
/Count 17
/First 14 0 R
/Last 14 0 R
/Type /Outlines
>>
endobj
6 0 obj
<<
/DestOutputProfile 15 0 R
/Info (sRGB IEC61966-2.1)
/OutputCondition (sRGB)
/OutputConditionIdentifier (Custom)
/RegistryName ()
/S /GTS_PDFA1
/Type /OutputIntent
>>
endobj
7 0 obj
<<
/Nums [0 16 0 R]
>>
endobj
8 0 obj
<<
/Count 9
/Kids [17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R]
/Type /Pages
>>
endobj
10 0 obj
<<
/Differences [24 /breve /caron /circumflex /dotaccent /hungarumlaut /ogonek /ring /tilde 39
/quotesingle 96 /grave 128 /bullet /dagger /daggerdbl /ellipsis /emdash /endash
/florin /fraction /guilsinglleft /guilsinglright /minus /perthousand /quotedblbase /quotedblleft /quotedblright /quoteleft
/quoteright /quotesinglbase /trademark /fi /fl /Lslash /OE /Scaron /Ydieresis /Zcaron
/dotlessi /lslash /oe /scaron /zcaron 160 /Euro 164 /currency 166
/brokenbar 168 /dieresis /copyright /ordfeminine 172 /logicalnot /.notdef /registered /macron
/degree /plusminus /twosuperior /threesuperior /acute /mu 183 /periodcentered /cedilla /onesuperior
/ordmasculine 188 /onequarter /onehalf /threequarters 192 /Agrave /Aacute /Acircumflex /Atilde
/Adieresis /Aring /AE /Ccedilla /Egrave /Eacute /Ecircumflex /Edieresis /Igrave /Iacute
/Icircumflex /Idieresis /Eth /Ntilde /Ograve /Oacute /Ocircumflex /Otilde /Odieresis /multiply
/Oslash /Ugrave /Uacute /Ucircumflex /Udieresis /Yacute /Thorn /germandbls /agrave /aacute
/acircumflex /atilde /adieresis /aring /ae /ccedilla /egrave /eacute /ecircumflex /edieresis
/igrave /iacute /icircumflex /idieresis /eth /ntilde /ograve /oacute /ocircumflex /otilde
/odieresis /divide /oslash /ugrave /uacute /ucircumflex /udieresis /yacute /thorn /ydieresis]
/Type /Encoding
>>
endobj
11 0 obj
<<
/BaseFont /Helvetica
/Encoding 10 0 R
/Name /Helv
/Subtype /Type1
/Type /Font
>>
endobj
12 0 obj
<<
/BaseFont /ZapfDingbats
/Name /ZaDb
/Subtype /Type1
/Type /Font
>>
endobj
13 0 obj
<<
/Kids [26 0 R]
>>
endobj
14 0 obj
<<
/Count 16
/Dest (Title)
/F 0
/First 27 0 R
/Last 28 0 R
/Parent 5 0 R
/Title (Population Pharmacokinetic Modelling of FE 999049, a Recombinant Human Follicle-Stimulating Hormone, in Healthy Women After Single Ascending Doses)
>>
endobj
15 0 obj
<<
/Length 2574
/Filter /FlateDecode
/N 3
/Range [0.0 1.0 0.0 1.0 0.0 1.0]
>>
stream
HyTSwoɞc
[5laQIBHADED2mtFOE.c}088GNg9w߽ '0 ֠Jb
2y.-;!KZ ^i"L0-
@8(r;q7Ly&Qq4j|9
V)gB0iW8#8wթ8_٥ʨQQj@&A)/g>'K t;\
ӥ$պFZUn(4T%)뫔0C&Zi8bxEB;Pӓ̹Aom?W=
x- [ 0}y)7ta>jT7@tܛ`q2ʀ&6ZLĄ?_yxg)˔zçLU*uSkSeO4?c. R
߁-25 S>ӣVd`rn~Y&+`;A4 A9 =-tl`;~p Gp| [`L`< "AYA+Cb(R, *T2B-
ꇆnQt}MA0alSx k&^>0|>_',G!"F$H:R!zFQd?r9\A&GrQhE]a4zBgE#H *B=0HIpp0MxJ$D1D, VĭKĻYdE"EI2EBGt4MzNr!YK ?%_(0J:EAiQ(()ӔWT6U@P+!~mDeԴ!hӦh/']B/ҏӿ?a0nhF!X8܌kc&5S6lIa2cKMA!E#ƒdV(kel
}}Cq9
N')].uJr
wG xR^[oƜchg`>b$*~ :Eb~,m,-ݖ,Y¬*6X[ݱF=3뭷Y~dó tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:˜O:ϸ8uJqnv=MmR 4
n3ܣkGݯz=[==<=GTB(/S,]6*-W:#7*e^YDY}UjAyT`#D="b{ų+ʯ:!kJ4Gmt}uC%K7YVfFY.=b?SƕƩȺy
چk5%4m7lqlioZlG+Zzmzy]?uuw|"űNwW&e֥ﺱ*|j5kyݭǯg^ykEklD_p߶7Dmo꿻1ml{Mś
nLl<9O [$h՛BdҞ@iءG&vVǥ8nRĩ7u\ЭD- u`ֲK³8%yhYѹJº;.!
zpg_XQKFAǿ=ȼ:ɹ8ʷ6˶5̵5͵6ζ7ϸ9к<Ѿ?DINU\dlvۀ܊ݖޢ)߯6DScs
2F[p(@Xr4Pm8Ww)Km
endstream
endobj
16 0 obj
<<
/S /D
/St 173
>>
endobj
17 0 obj
<<
/Contents 29 0 R
/Type /Page
/Resources <<
/Font <<
/F1 30 0 R
/F2 31 0 R
/F3 32 0 R
/F4 33 0 R
>>
/XObject <<
/Xf1 34 0 R
>>
>>
/Annots [35 0 R 36 0 R]
/Parent 8 0 R
/MediaBox [0 0 595 842]
>>
endobj
18 0 obj
<<
/Annots [37 0 R 38 0 R 39 0 R 40 0 R]
/Contents [41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R]
/CropBox [0.0 0.0 595.276 790.866]
/MediaBox [0.0 0.0 595.276 790.866]
/Parent 8 0 R
/Resources <<
/ColorSpace <<
/Cs6 [/ICCBased 49 0 R]
/Cs8 [/Separation /Orange [/ICCBased 49 0 R]
50 0 R]
/Cs9 [/Separation /Orange_Spr2 [/ICCBased 49 0 R]
51 0 R]
>>
/ExtGState <<
/GS2 52 0 R
/GS4 53 0 R
>>
/Font <<
/F1 54 0 R
/F2 55 0 R
/F3 56 0 R
/F4 57 0 R
/F5 58 0 R
/F6 59 0 R
>>
/ProcSet [/PDF /Text /ImageC /ImageI /ImageB]
/Properties <<
/MC1 60 0 R
/MC2 61 0 R
/MC3 62 0 R
/MC4 63 0 R
>>
/Shading <<
/Sh1 64 0 R
/Sh10 65 0 R
/Sh100 66 0 R
/Sh101 67 0 R
/Sh102 68 0 R
/Sh103 69 0 R
/Sh104 70 0 R
/Sh105 71 0 R
/Sh106 72 0 R
/Sh107 73 0 R
/Sh108 74 0 R
/Sh109 75 0 R
/Sh11 76 0 R
/Sh110 77 0 R
/Sh111 78 0 R
/Sh112 79 0 R
/Sh113 80 0 R
/Sh114 81 0 R
/Sh115 82 0 R
/Sh116 83 0 R
/Sh117 84 0 R
/Sh118 85 0 R
/Sh119 86 0 R
/Sh12 87 0 R
/Sh120 88 0 R
/Sh121 89 0 R
/Sh122 90 0 R
/Sh123 91 0 R
/Sh124 92 0 R
/Sh125 93 0 R
/Sh126 94 0 R
/Sh127 95 0 R
/Sh128 96 0 R
/Sh129 97 0 R
/Sh13 98 0 R
/Sh130 99 0 R
/Sh131 100 0 R
/Sh132 101 0 R
/Sh133 102 0 R
/Sh134 103 0 R
/Sh135 104 0 R
/Sh136 105 0 R
/Sh137 106 0 R
/Sh138 107 0 R
/Sh139 108 0 R
/Sh14 109 0 R
/Sh140 110 0 R
/Sh141 111 0 R
/Sh142 112 0 R
/Sh143 113 0 R
/Sh144 114 0 R
/Sh145 115 0 R
/Sh146 116 0 R
/Sh147 117 0 R
/Sh148 118 0 R
/Sh149 119 0 R
/Sh15 120 0 R
/Sh150 121 0 R
/Sh151 122 0 R
/Sh152 123 0 R
/Sh153 124 0 R
/Sh154 125 0 R
/Sh155 126 0 R
/Sh156 127 0 R
/Sh157 128 0 R
/Sh158 129 0 R
/Sh159 130 0 R
/Sh16 131 0 R
/Sh160 132 0 R
/Sh161 133 0 R
/Sh162 134 0 R
/Sh163 135 0 R
/Sh164 136 0 R
/Sh165 137 0 R
/Sh166 138 0 R
/Sh167 139 0 R
/Sh168 140 0 R
/Sh169 141 0 R
/Sh17 142 0 R
/Sh170 143 0 R
/Sh171 144 0 R
/Sh172 145 0 R
/Sh173 146 0 R
/Sh174 147 0 R
/Sh175 148 0 R
/Sh176 149 0 R
/Sh177 150 0 R
/Sh178 151 0 R
/Sh179 152 0 R
/Sh18 153 0 R
/Sh180 154 0 R
/Sh181 155 0 R
/Sh182 156 0 R
/Sh183 157 0 R
/Sh184 158 0 R
/Sh185 159 0 R
/Sh186 160 0 R
/Sh187 161 0 R
/Sh188 162 0 R
/Sh189 163 0 R
/Sh19 164 0 R
/Sh190 165 0 R
/Sh191 166 0 R
/Sh192 167 0 R
/Sh193 168 0 R
/Sh194 169 0 R
/Sh195 170 0 R
/Sh196 171 0 R
/Sh197 172 0 R
/Sh198 173 0 R
/Sh199 174 0 R
/Sh2 175 0 R
/Sh20 176 0 R
/Sh200 177 0 R
/Sh201 178 0 R
/Sh202 179 0 R
/Sh203 180 0 R
/Sh204 181 0 R
/Sh205 182 0 R
/Sh206 183 0 R
/Sh207 184 0 R
/Sh208 185 0 R
/Sh209 186 0 R
/Sh21 187 0 R
/Sh210 188 0 R
/Sh211 189 0 R
/Sh212 190 0 R
/Sh213 191 0 R
/Sh214 192 0 R
/Sh215 193 0 R
/Sh216 194 0 R
/Sh217 195 0 R
/Sh218 196 0 R
/Sh219 197 0 R
/Sh22 198 0 R
/Sh220 199 0 R
/Sh221 200 0 R
/Sh222 201 0 R
/Sh223 202 0 R
/Sh224 203 0 R
/Sh225 204 0 R
/Sh226 205 0 R
/Sh227 206 0 R
/Sh228 207 0 R
/Sh229 208 0 R
/Sh23 209 0 R
/Sh230 210 0 R
/Sh231 211 0 R
/Sh232 212 0 R
/Sh233 213 0 R
/Sh234 214 0 R
/Sh235 215 0 R
/Sh236 216 0 R
/Sh237 217 0 R
/Sh238 218 0 R
/Sh239 219 0 R
/Sh24 220 0 R
/Sh240 221 0 R
/Sh241 222 0 R
/Sh242 223 0 R
/Sh243 224 0 R
/Sh244 225 0 R
/Sh245 226 0 R
/Sh246 227 0 R
/Sh247 228 0 R
/Sh248 229 0 R
/Sh249 230 0 R
/Sh25 231 0 R
/Sh250 232 0 R
/Sh251 233 0 R
/Sh252 234 0 R
/Sh253 235 0 R
/Sh254 236 0 R
/Sh255 237 0 R
/Sh256 238 0 R
/Sh257 239 0 R
/Sh258 240 0 R
/Sh259 241 0 R
/Sh26 242 0 R
/Sh260 243 0 R
/Sh261 244 0 R
/Sh262 245 0 R
/Sh263 246 0 R
/Sh264 247 0 R
/Sh265 248 0 R
/Sh266 249 0 R
/Sh267 250 0 R
/Sh268 251 0 R
/Sh269 252 0 R
/Sh27 253 0 R
/Sh270 254 0 R
/Sh271 255 0 R
/Sh272 256 0 R
/Sh273 257 0 R
/Sh274 258 0 R
/Sh275 259 0 R
/Sh276 260 0 R
/Sh277 261 0 R
/Sh278 262 0 R
/Sh279 263 0 R
/Sh28 264 0 R
/Sh280 265 0 R
/Sh281 266 0 R
/Sh282 267 0 R
/Sh283 268 0 R
/Sh284 269 0 R
/Sh285 270 0 R
/Sh286 271 0 R
/Sh287 272 0 R
/Sh288 273 0 R
/Sh289 274 0 R
/Sh29 275 0 R
/Sh290 276 0 R
/Sh291 277 0 R
/Sh292 278 0 R
/Sh293 279 0 R
/Sh294 280 0 R
/Sh295 281 0 R
/Sh296 282 0 R
/Sh297 283 0 R
/Sh298 284 0 R
/Sh299 285 0 R
/Sh3 286 0 R
/Sh30 287 0 R
/Sh300 288 0 R
/Sh301 289 0 R
/Sh302 290 0 R
/Sh303 291 0 R
/Sh304 292 0 R
/Sh305 293 0 R
/Sh306 294 0 R
/Sh307 295 0 R
/Sh308 296 0 R
/Sh309 297 0 R
/Sh31 298 0 R
/Sh310 299 0 R
/Sh311 300 0 R
/Sh312 301 0 R
/Sh313 302 0 R
/Sh314 303 0 R
/Sh315 304 0 R
/Sh316 305 0 R
/Sh317 306 0 R
/Sh318 307 0 R
/Sh319 308 0 R
/Sh32 309 0 R
/Sh320 310 0 R
/Sh321 311 0 R
/Sh322 312 0 R
/Sh323 313 0 R
/Sh324 314 0 R
/Sh325 315 0 R
/Sh326 316 0 R
/Sh327 317 0 R
/Sh328 318 0 R
/Sh329 319 0 R
/Sh33 320 0 R
/Sh330 321 0 R
/Sh331 322 0 R
/Sh332 323 0 R
/Sh333 324 0 R
/Sh334 325 0 R
/Sh335 326 0 R
/Sh336 327 0 R
/Sh337 328 0 R
/Sh338 329 0 R
/Sh339 330 0 R
/Sh34 331 0 R
/Sh340 332 0 R
/Sh341 333 0 R
/Sh342 334 0 R
/Sh343 335 0 R
/Sh344 336 0 R
/Sh345 337 0 R
/Sh346 338 0 R
/Sh347 339 0 R
/Sh348 340 0 R
/Sh349 341 0 R
/Sh35 342 0 R
/Sh350 343 0 R
/Sh351 344 0 R
/Sh352 345 0 R
/Sh353 346 0 R
/Sh354 347 0 R
/Sh355 348 0 R
/Sh356 349 0 R
/Sh357 350 0 R
/Sh358 351 0 R
/Sh359 352 0 R
/Sh36 353 0 R
/Sh360 354 0 R
/Sh361 355 0 R
/Sh362 356 0 R
/Sh363 357 0 R
/Sh364 358 0 R
/Sh365 359 0 R
/Sh366 360 0 R
/Sh367 361 0 R
/Sh368 362 0 R
/Sh369 363 0 R
/Sh37 364 0 R
/Sh370 365 0 R
/Sh371 366 0 R
/Sh372 367 0 R
/Sh373 368 0 R
/Sh374 369 0 R
/Sh375 370 0 R
/Sh376 371 0 R
/Sh377 372 0 R
/Sh378 373 0 R
/Sh379 374 0 R
/Sh38 375 0 R
/Sh380 376 0 R
/Sh381 377 0 R
/Sh382 378 0 R
/Sh383 379 0 R
/Sh384 380 0 R
/Sh385 381 0 R
/Sh386 382 0 R
/Sh387 383 0 R
/Sh388 384 0 R
/Sh389 385 0 R
/Sh39 386 0 R
/Sh390 387 0 R
/Sh391 388 0 R
/Sh392 389 0 R
/Sh393 390 0 R
/Sh394 391 0 R
/Sh395 392 0 R
/Sh396 393 0 R
/Sh397 394 0 R
/Sh398 395 0 R
/Sh399 396 0 R
/Sh4 397 0 R
/Sh40 398 0 R
/Sh400 399 0 R
/Sh401 400 0 R
/Sh402 401 0 R
/Sh403 402 0 R
/Sh404 403 0 R
/Sh405 404 0 R
/Sh406 405 0 R
/Sh407 406 0 R
/Sh408 407 0 R
/Sh409 408 0 R
/Sh41 409 0 R
/Sh410 410 0 R
/Sh411 411 0 R
/Sh412 412 0 R
/Sh413 413 0 R
/Sh414 414 0 R
/Sh415 415 0 R
/Sh416 416 0 R
/Sh417 417 0 R
/Sh418 418 0 R
/Sh419 419 0 R
/Sh42 420 0 R
/Sh420 421 0 R
/Sh421 422 0 R
/Sh422 423 0 R
/Sh423 424 0 R
/Sh424 425 0 R
/Sh425 426 0 R
/Sh426 427 0 R
/Sh427 428 0 R
/Sh428 429 0 R
/Sh429 430 0 R
/Sh43 431 0 R
/Sh430 432 0 R
/Sh431 433 0 R
/Sh432 434 0 R
/Sh433 435 0 R
/Sh434 436 0 R
/Sh435 437 0 R
/Sh436 438 0 R
/Sh437 439 0 R
/Sh438 440 0 R
/Sh439 441 0 R
/Sh44 442 0 R
/Sh440 443 0 R
/Sh441 444 0 R
/Sh442 445 0 R
/Sh443 446 0 R
/Sh444 447 0 R
/Sh445 448 0 R
/Sh446 449 0 R
/Sh447 450 0 R
/Sh448 451 0 R
/Sh449 452 0 R
/Sh45 453 0 R
/Sh450 454 0 R
/Sh451 455 0 R
/Sh452 456 0 R
/Sh453 457 0 R
/Sh454 458 0 R
/Sh455 459 0 R
/Sh456 460 0 R
/Sh457 461 0 R
/Sh458 462 0 R
/Sh459 463 0 R
/Sh46 464 0 R
/Sh460 465 0 R
/Sh461 466 0 R
/Sh462 467 0 R
/Sh463 468 0 R
/Sh464 469 0 R
/Sh465 470 0 R
/Sh466 471 0 R
/Sh467 472 0 R
/Sh468 473 0 R
/Sh469 474 0 R
/Sh47 475 0 R
/Sh470 476 0 R
/Sh471 477 0 R
/Sh472 478 0 R
/Sh473 479 0 R
/Sh474 480 0 R
/Sh475 481 0 R
/Sh476 482 0 R
/Sh477 483 0 R
/Sh478 484 0 R
/Sh479 485 0 R
/Sh48 486 0 R
/Sh480 487 0 R
/Sh481 488 0 R
/Sh482 489 0 R
/Sh483 490 0 R
/Sh484 491 0 R
/Sh485 492 0 R
/Sh486 493 0 R
/Sh487 494 0 R
/Sh488 495 0 R
/Sh489 496 0 R
/Sh49 497 0 R
/Sh490 498 0 R
/Sh491 499 0 R
/Sh492 500 0 R
/Sh493 501 0 R
/Sh494 502 0 R
/Sh495 503 0 R
/Sh496 504 0 R
/Sh497 505 0 R
/Sh498 506 0 R
/Sh499 507 0 R
/Sh5 508 0 R
/Sh50 509 0 R
/Sh500 510 0 R
/Sh501 511 0 R
/Sh502 512 0 R
/Sh503 513 0 R
/Sh504 514 0 R
/Sh505 515 0 R
/Sh506 516 0 R
/Sh507 517 0 R
/Sh508 518 0 R
/Sh509 519 0 R
/Sh51 520 0 R
/Sh510 521 0 R
/Sh511 522 0 R
/Sh512 523 0 R
/Sh513 524 0 R
/Sh514 525 0 R
/Sh515 526 0 R
/Sh516 527 0 R
/Sh517 528 0 R
/Sh518 529 0 R
/Sh519 530 0 R
/Sh52 531 0 R
/Sh520 532 0 R
/Sh521 533 0 R
/Sh522 534 0 R
/Sh523 535 0 R
/Sh524 536 0 R
/Sh525 537 0 R
/Sh526 538 0 R
/Sh527 539 0 R
/Sh528 540 0 R
/Sh529 541 0 R
/Sh53 542 0 R
/Sh530 543 0 R
/Sh531 544 0 R
/Sh532 545 0 R
/Sh533 546 0 R
/Sh534 547 0 R
/Sh535 548 0 R
/Sh536 549 0 R
/Sh537 550 0 R
/Sh538 551 0 R
/Sh539 552 0 R
/Sh54 553 0 R
/Sh540 554 0 R
/Sh541 555 0 R
/Sh542 556 0 R
/Sh543 557 0 R
/Sh544 558 0 R
/Sh545 559 0 R
/Sh546 560 0 R
/Sh547 561 0 R
/Sh548 562 0 R
/Sh549 563 0 R
/Sh55 564 0 R
/Sh550 565 0 R
/Sh551 566 0 R
/Sh552 567 0 R
/Sh553 568 0 R
/Sh554 569 0 R
/Sh555 570 0 R
/Sh556 571 0 R
/Sh557 572 0 R
/Sh558 573 0 R
/Sh559 574 0 R
/Sh56 575 0 R
/Sh560 576 0 R
/Sh561 577 0 R
/Sh562 578 0 R
/Sh563 579 0 R
/Sh564 580 0 R
/Sh565 581 0 R
/Sh566 582 0 R
/Sh567 583 0 R
/Sh568 584 0 R
/Sh569 585 0 R
/Sh57 586 0 R
/Sh570 587 0 R
/Sh571 588 0 R
/Sh572 589 0 R
/Sh573 590 0 R
/Sh574 591 0 R
/Sh575 592 0 R
/Sh576 593 0 R
/Sh577 594 0 R
/Sh578 595 0 R
/Sh579 596 0 R
/Sh58 597 0 R
/Sh580 598 0 R
/Sh581 599 0 R
/Sh582 600 0 R
/Sh583 601 0 R
/Sh584 602 0 R
/Sh585 603 0 R
/Sh586 604 0 R
/Sh587 605 0 R
/Sh588 606 0 R
/Sh589 607 0 R
/Sh59 608 0 R
/Sh590 609 0 R
/Sh591 610 0 R
/Sh592 611 0 R
/Sh593 612 0 R
/Sh594 613 0 R
/Sh595 614 0 R
/Sh596 615 0 R
/Sh597 616 0 R
/Sh598 617 0 R
/Sh599 618 0 R
/Sh6 619 0 R
/Sh60 620 0 R
/Sh600 621 0 R
/Sh601 622 0 R
/Sh602 623 0 R
/Sh603 624 0 R
/Sh604 625 0 R
/Sh605 626 0 R
/Sh606 627 0 R
/Sh607 628 0 R
/Sh608 629 0 R
/Sh609 630 0 R
/Sh61 631 0 R
/Sh610 632 0 R
/Sh611 633 0 R
/Sh612 634 0 R
/Sh613 635 0 R
/Sh614 636 0 R
/Sh615 637 0 R
/Sh616 638 0 R
/Sh617 639 0 R
/Sh618 640 0 R
/Sh619 641 0 R
/Sh62 642 0 R
/Sh620 643 0 R
/Sh621 644 0 R
/Sh622 645 0 R
/Sh623 646 0 R
/Sh624 647 0 R
/Sh625 648 0 R
/Sh626 649 0 R
/Sh627 650 0 R
/Sh628 651 0 R
/Sh629 652 0 R
/Sh63 653 0 R
/Sh630 654 0 R
/Sh631 655 0 R
/Sh64 656 0 R
/Sh65 657 0 R
/Sh66 658 0 R
/Sh67 659 0 R
/Sh68 660 0 R
/Sh69 661 0 R
/Sh7 662 0 R
/Sh70 663 0 R
/Sh71 664 0 R
/Sh72 665 0 R
/Sh73 666 0 R
/Sh74 667 0 R
/Sh75 668 0 R
/Sh76 669 0 R
/Sh77 670 0 R
/Sh78 671 0 R
/Sh79 672 0 R
/Sh8 673 0 R
/Sh80 674 0 R
/Sh81 675 0 R
/Sh82 676 0 R
/Sh83 677 0 R
/Sh84 678 0 R
/Sh85 679 0 R
/Sh86 680 0 R
/Sh87 681 0 R
/Sh88 682 0 R
/Sh89 683 0 R
/Sh9 684 0 R
/Sh90 685 0 R
/Sh91 686 0 R
/Sh92 687 0 R
/Sh93 688 0 R
/Sh94 689 0 R
/Sh95 690 0 R
/Sh96 691 0 R
/Sh97 692 0 R
/Sh98 693 0 R
/Sh99 694 0 R
>>
/XObject <<
/Im1 695 0 R
/Im2 696 0 R
/Im3 697 0 R
/Im4 698 0 R
/Im5 699 0 R
/Im6 700 0 R
/Im7 701 0 R
/Im8 702 0 R
/Im9 703 0 R
/X1 704 0 R
/X10 705 0 R
/X11 706 0 R
/X12 707 0 R
/X13 708 0 R
/X14 709 0 R
/X2 710 0 R
/X3 711 0 R
/X4 712 0 R
/X5 713 0 R
/X6 714 0 R
/X7 715 0 R
/X8 716 0 R
/X9 717 0 R
>>
>>
/Rotate 0
/Thumb 718 0 R
/Type /Page
>>
endobj
19 0 obj
<<
/Annots [719 0 R 720 0 R 721 0 R 722 0 R 723 0 R 724 0 R 725 0 R 726 0 R 727 0 R]
/Contents 728 0 R
/CropBox [0.0 0.0 595.276 790.866]
/MediaBox [0.0 0.0 595.276 790.866]
/Parent 8 0 R
/Resources <<
/ColorSpace <<
/Cs6 [/ICCBased 49 0 R]
>>
/ExtGState <<
/GS1 729 0 R
>>
/Font <<
/F1 54 0 R
/F2 55 0 R
/F4 57 0 R
/F5 58 0 R
/F7 730 0 R
/F8 731 0 R
>>
/ProcSet [/PDF /Text]
/Properties <<
/MC5 62 0 R
/MC6 63 0 R
>>
/XObject <<
>>
>>
/Rotate 0
/Thumb 732 0 R
/Type /Page
>>
endobj
20 0 obj
<<
/Annots [733 0 R 734 0 R 735 0 R 736 0 R 737 0 R 738 0 R 739 0 R 740 0 R 741 0 R 742 0 R]
/Contents 743 0 R
/CropBox [0.0 0.0 595.276 790.866]
/MediaBox [0.0 0.0 595.276 790.866]
/Parent 8 0 R
/Resources <<
/ColorSpace <<
/Cs6 [/ICCBased 49 0 R]
>>
/ExtGState <<
/GS1 729 0 R
>>
/Font <<
/F1 54 0 R
/F10 744 0 R
/F11 745 0 R
/F2 55 0 R
/F5 58 0 R
/F7 730 0 R
/F8 731 0 R
/F9 746 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/Properties <<
/MC7 747 0 R
/MC8 62 0 R
/MC9 63 0 R
>>
/XObject <<
/Im24 748 0 R
>>
>>
/Rotate 0
/Thumb 749 0 R
/Type /Page
>>
endobj
21 0 obj
<<
/Annots [750 0 R 751 0 R 752 0 R 753 0 R 754 0 R]
/Contents 755 0 R
/CropBox [0.0 0.0 595.276 790.866]
/MediaBox [0.0 0.0 595.276 790.866]
/Parent 8 0 R
/Resources <<
/ColorSpace <<
/Cs6 [/ICCBased 49 0 R]
>>
/ExtGState <<
/GS1 729 0 R
>>
/Font <<
/F1 54 0 R
/F10 744 0 R
/F11 745 0 R
/F12 756 0 R
/F2 55 0 R
/F5 58 0 R
/F7 730 0 R
/F8 731 0 R
/F9 746 0 R
>>
/ProcSet [/PDF /Text]
/Properties <<
/MC10 62 0 R
/MC11 63 0 R
>>
/XObject <<
>>
>>
/Rotate 0
/Thumb 757 0 R
/Type /Page
>>
endobj
22 0 obj
<<
/Annots [758 0 R 759 0 R 760 0 R 761 0 R 762 0 R 763 0 R]
/Contents 764 0 R
/CropBox [0.0 0.0 595.276 790.866]
/MediaBox [0.0 0.0 595.276 790.866]
/Parent 8 0 R
/Resources <<
/ColorSpace <<
/Cs6 [/ICCBased 49 0 R]
>>
/ExtGState <<
/GS1 729 0 R
>>
/Font <<
/F1 54 0 R
/F13 765 0 R
/F2 55 0 R
/F5 58 0 R
/F7 730 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/Properties <<
/MC12 747 0 R
/MC13 62 0 R
/MC14 63 0 R
>>
/XObject <<
/Im25 766 0 R
>>
>>
/Rotate 0
/Thumb 767 0 R
/Type /Page
>>
endobj
23 0 obj
<<
/Annots [768 0 R 769 0 R 770 0 R 771 0 R 772 0 R 773 0 R 774 0 R 775 0 R]
/Contents 776 0 R
/CropBox [0.0 0.0 595.276 790.866]
/MediaBox [0.0 0.0 595.276 790.866]
/Parent 8 0 R
/Resources <<
/ColorSpace <<
/Cs6 [/ICCBased 49 0 R]
>>
/ExtGState <<
/GS1 729 0 R
>>
/Font <<
/F1 54 0 R
/F2 55 0 R
/F5 58 0 R
/F7 730 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/Properties <<
/MC15 747 0 R
/MC16 62 0 R
/MC17 63 0 R
>>
/XObject <<
/Im26 777 0 R
>>
>>
/Rotate 0
/Thumb 778 0 R
/Type /Page
>>
endobj
24 0 obj
<<
/Annots [779 0 R 780 0 R]
/Contents 781 0 R
/CropBox [0.0 0.0 595.276 790.866]
/MediaBox [0.0 0.0 595.276 790.866]
/Parent 8 0 R
/Resources <<
/ColorSpace <<
/Cs6 [/ICCBased 49 0 R]
>>
/ExtGState <<
/GS1 729 0 R
>>
/Font <<
/F1 54 0 R
/F2 55 0 R
/F5 58 0 R
/F7 730 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/Properties <<
/MC18 747 0 R
/MC19 62 0 R
/MC20 63 0 R
>>
/XObject <<
/Im27 782 0 R
>>
>>
/Rotate 0
/Thumb 783 0 R
/Type /Page
>>
endobj
25 0 obj
<<
/Contents 784 0 R
/CropBox [0.0 0.0 595.276 790.866]
/MediaBox [0.0 0.0 595.276 790.866]
/Parent 8 0 R
/Resources <<
/ColorSpace <<
/Cs6 [/ICCBased 49 0 R]
>>
/ExtGState <<
/GS1 729 0 R
>>
/Font <<
/F1 54 0 R
/F2 55 0 R
>>
/ProcSet [/PDF /Text]
/Properties <<
/MC21 62 0 R
/MC22 63 0 R
>>
/XObject <<
>>
>>
/Rotate 0
/Thumb 785 0 R
/Type /Page
>>
endobj
26 0 obj
<<
/Limits [(ASec1) (lTab2)]
/Names [(ASec1) 786 0 R (ASec2) 787 0 R (ASec3) 788 0 R (ASec4) 789 0 R (Abs1) 790 0 R
(Ack) 791 0 R (Bib1) 792 0 R (Sec1) 793 0 R (Sec2) 794 0 R (Sec3) 795 0 R
(Sec4) 796 0 R (Sec5) 797 0 R (Sec6) 798 0 R (Sec7) 799 0 R (Sec8) 800 0 R
(Sec9) 801 0 R (Title) 802 0 R (lCR1) 803 0 R (lCR10) 804 0 R (lCR11) 805 0 R
(lCR12) 806 0 R (lCR13) 807 0 R (lCR14) 808 0 R (lCR15) 809 0 R (lCR16) 810 0 R
(lCR17) 811 0 R (lCR18) 812 0 R (lCR19) 813 0 R (lCR2) 814 0 R (lCR20) 815 0 R
(lCR21) 816 0 R (lCR22) 817 0 R (lCR23) 818 0 R (lCR24) 819 0 R (lCR25) 820 0 R
(lCR3) 821 0 R (lCR4) 822 0 R (lCR5) 823 0 R (lCR6) 824 0 R (lCR7) 825 0 R
(lCR8) 826 0 R (lCR9) 827 0 R (lEqu1) 828 0 R (lEqu2) 829 0 R (lEqu3) 830 0 R
(lEqu4) 831 0 R (lEqu5) 832 0 R (lEqu6) 833 0 R (lFig1) 834 0 R (lFig2) 835 0 R
(lFig3) 836 0 R (lFig4) 837 0 R (lSec1) 793 0 R (lSec2) 794 0 R (lSec3) 795 0 R
(lSec4) 796 0 R (lSec5) 797 0 R (lSec6) 798 0 R (lSec7) 799 0 R (lSec8) 800 0 R
(lSec9) 801 0 R (lTab1) 838 0 R (lTab2) 839 0 R]
>>
endobj
27 0 obj
<<
/Count 4
/Dest (Abs1)
/F 0
/First 840 0 R
/Last 841 0 R
/Next 842 0 R
/Parent 14 0 R
/Title (Abstract)
>>
endobj
28 0 obj
<<
/Count 0
/Dest (Bib1)
/F 0
/Parent 14 0 R
/Prev 843 0 R
/Title (References)
>>
endobj
29 0 obj
<<
/Length 1268
/Filter /FlateDecode
>>
stream
xWKsFV/蓳 nF1`^"K(H<vsL嘞K:)
4x.=2~U'tA_ꗞK_%
C5BUQuMamd!c]o|;hۡ+/$W9[l6z6C'/M`Цj'/+{p&e
ILbrn1aJ>!
hs?δILhX!gKg- Y;Zs `, ]"T8&Bޥ0|xjo
2'ߋEj>, mupi+wg9~aEoQ]V5ZV4f!X<NҠZ!*PlW+f:lƄEA1Z{WFs=GV!}
v|Ns}Ԛq Cs`K=xۻ]SWOf{ah*ɵ<
st0v^U
Ϯ%=OPP
N>6ZϢG$0*rSVt98^GUzJ{L;$$ye\|+ OKi =J4,+KB2k#{^>ƻ;!{4ZgImԟuca )P1qwrw-w$)"14E-@,Ґ_H24rsزLwosp
={3M=tQdpIf%5!Zbo?-!BKNh&Ri9!01b;KC[,OFNl;XuTqWfvĶGzJqFl!Q1Ew(lWi<[/$<8=jzSMAmV*j _+d
endstream
endobj
30 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Bold
/Encoding /WinAnsiEncoding
>>
endobj
31 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica
/Encoding /WinAnsiEncoding
>>
endobj
32 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Oblique
/Encoding /WinAnsiEncoding
>>
endobj
33 0 obj
<<
/Subtype /Type0
/Type /Font
/BaseFont /RNNYAJ+LiberationSans
/Encoding /Identity-H
/DescendantFonts [844 0 R]
/ToUnicode 845 0 R
>>
endobj
34 0 obj
<<
/Length 625
/Subtype /Form
/Filter /FlateDecode
/Type /XObject
/Matrix [1 0 0 1 0 0]
/FormType 1
/Resources <<
/ExtGState <<
/GS0 846 0 R
>>
/ProcSet [/PDF /Text]
/Font <<
/TT0 847 0 R
>>
>>
/BBox [0 0 595.28 159.74]
>>
stream
HTn@WqtϳH`qJ6$d!T Vݵ3ՏG|Y3I-RMpZk>P*ϒ߹7={#`PVΞEH$Fy߹)4tC$Yd,QP#i?08bYب/ )foZ# bbGNGr9P|(DYPjCɧI#eHwabkX. [o[JPVW%5?g5!q4*Xu,B3Ȑ+q)
(]):pByN
l:l@̺!Y)mM-Z/@Mp/(UTTRs%exb $ۖʹ/hJFդI0YCK#Hr5=$jt* X6 D=CBrBQ$fsI7F_fHPРrh( A˽bC6%Ot|%6t2)\Y ev`^ywjb$2Y8" ۽|w{:ovR[Hv~[O(nA%~wxzke|^ .G
endstream
endobj
35 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1007/s40268-016-0129-9)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [57 502 183.19 512]
>>
endobj
36 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1007/s40268-016-0129-9)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [278.2 362 467.76 372]
>>
endobj
37 0 obj
<<
/AP <<
/N 848 0 R
>>
/Border [0 0 0]
/Dest (lCR1)
/F 4
/Rect [485.461 112.195 490.45 122.117]
/Subtype /Link
/Type /Annot
>>
endobj
38 0 obj
<<
/AP <<
/N 849 0 R
>>
/Border [0 0 0]
/Dest (lCR2)
/F 4
/Rect [515.962 74.835 520.951 84.756]
/Subtype /Link
/Type /Annot
>>
endobj
39 0 obj
<<
/A <<
/S /URI
/URI (http://crossmark.crossref.org/dialog/?doi=10.1007/s40268-016-0129-9&domain=pdf)
>>
/AP <<
/N 850 0 R
>>
/Border [0 0 0]
/F 4
/Rect [469.417 731.282 500.938 772.157]
/Subtype /Link
/Type /Annot
>>
endobj
40 0 obj
<<
/A <<
/S /URI
/URI (http://crossmark.crossref.org/dialog/?doi=10.1007/s40268-016-0129-9&domain=pdf)
>>
/AP <<
/N 851 0 R
>>
/Border [0 0 0]
/F 4
/Rect [500.938 737.801 545.499 752.712]
/Subtype /Link
/Type /Annot
>>
endobj
41 0 obj
<<
/Length 18522
/Filter /FlateDecode
>>
stream
HWro>vGځȑ&I a6GV܂G:P̗r&]OESmEDbfՁd&[ȅT:RZ+L28gg82\[Kh+cH]I(V $YI:e,fic2IV?q#1xWh1!!QEy1gN%1ç뭹gI,"CiCE"VM$'P%8$bA29D7g.γrՁQq/L+m"OC2!}=JGX(ˇGWk)UDgGoӮ$M\RLx_IuD[^Q:9N;0L^ٯn_]QWF$^~ݤ6EwEFJjl/,k^WE}|'ʸ73yV'$W973EQUG~V~Jְ!+YWlAf[W\oF~ Lpnt6o\{ͫP.ooA2U,.{wu3mdR{@oq9HtINo0nW8R=j؍)S9u 3`(!h#fROGXS^ܸD!J 26*Ál.ibH\ĕAIoѻ*`G'a
ޟx1+4>ӽ{4Bɔan7v6 @rA ea
ׇE(q1X1m DؘMmZ3#q(z%@]D.]}ypT,K$-R,~iaA0|l1 !@V6 }T!ʔ]N5`<.J/ਵv[UO$P@"2Eĩ-_enK_fQWh_[%+COim|0-$'eJ2Xh-J)lcaVݗxÖy6um~[QZ֒eMekE^tDžܽ27E ;ߜ'̤Ymz:o+X0{x]]fzQyc_%u\+Ϻ1=#?_f#x|/L.q2x_qnŭEoC%MCc;F[qMbMJ
r%inW%#nR9)tlj IfY8qɈGda85'vDjKt_
wW,K`ܳn0f7
d,,)Ͷ`KV}/iUhqM>d&ɣ:]qJ]J28)J":0=b[7K\40^LqAd}BozoxEC rMih>Wj%kKoj\f}Mj7
rAHMjjmyB{d!~T5Tqqr
˼"*܆*3@TT,-- PIFm`ƢY^5A 5&ЩxPZw<